Stable RNA interference rules for silencing
نویسندگان
چکیده
منابع مشابه
Stable gene silencing in zebrafish with spatiotemporally targetable RNA interference.
The ability to regulate gene activity in a spatiotemporally controllable manner is vital for biological discovery that will impact disease diagnosis and treatment. While conditional gene silencing is possible in other genetic model organisms, this technology is largely unavailable in zebrafish, an important vertebrate model organism for functional gene discovery. Here, using short hairpin RNAs ...
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Over the past two decades, dramatic advances in the role of RNA in normal health and disease have been greatly expanded. During development Small RNA molecules regulate eukaryotic gene expression and also during responses to stress including viral infection. RNA interference (RNAi) is a highly conserved process in eukaryotes that leads to post-transcriptional gene silencing through degradation ...
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Eight years ago, Craig Mello, Andrew Fire, and their coworkers provided the first demonstration that double-stranded RNA (dsRNA) triggers the gene-silencing technique that we now call RNA interference (RNAi). For this landmark discovery, Mello and Fire are honored with this year's Nobel Prize in Physiology or Medicine.
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2013
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb2895